13 Strongest antibiotics for staph infection

Staph infection especially the “methicillin-resistant Staphylococcus aureus infections kill 11,000 people each year in the United States and the pathogen is considered one of the world’s worst drug-resistant microbes,” said Gautam Dantas, a professor of pathology and immunology.

This means that it will take the strongest antibiotic for a staph infection to adequately eradicate some Staph aureus infections.

Whatever antibiotic you use must be because of the type of infection you have, its severity, and the site of action.

Here comes the question: Which type of Staph infection do you need a strong antibiotic for? Seek medical counsel and treatment in this regard.

strongest antibiotics for staph infections

Antibiotics for Staphylococcus Infection


Various kinds of honey are being tested as a means to guard against staph bacteria growth since antibiotic resistance is becoming a growing problem.

It has been found that manuka honey has antimicrobial activity and enhances the effects of certain antibiotics. However, it is still in its experimental stage.

Strongest Antibiotic Drugs. 

Researchers at Washington University, led by Gautam Dantas, Ph.D., have successfully eliminated MRSA infection in culture and in laboratory mice by using three antibiotics that were previously believed to be useless.

The three antibiotics are tazobactam, meropenem, and piperacillin. Other antibiotics that were used in this test include;

  • Linezolid: In research carried out in 2019 by Kimberly et al., linezolid was the most effective antibiotic against MRSA isolates with an inhibition level of 100 percent.
  • Vancomycin (100): vancomycin is active only with respect to Gram-positive bacteria. It is the most powerful of all of the known antibiotics with respect to S. aureus and Staphylococcus epidermis, including methicillin- and cephalosporin-resistant strains.
  • Gentamicin (100): is used to treat severe or serious bacterial infections.
  • Clindamycin (86): is a strong broad-spectrum antibiotic, typically prescribed for serious infections, such as life-threatening methicillin-resistant Staphylococcus aureus (MRSA) skin infections.
  • Rifampin (100): rifampin in combination with other antimicrobials has proved efficacious in the treatment of severe staphylococcal bone and joint infections.
  • Nitrofurantoin (100): Macrodantin (nitrofurantoin) and Amoxil (amoxicillin) are antibiotics prescribed to treat or prevent urinary tract infections. Amoxicillin is different from nitrofurantoin.
  • Trimethoprim-sulfamethoxazole: In that same research, TSM had an inhibition level of 95 percent, which was 5% lower than Linezolid.
  • Tetracyclines: In that same research, tetracycline was effective against MRSA isolates in 94%. 
  • Oxacillin (73): is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.
  • Erythromycin (65): it belongs to a group of antibiotics called macrolide antibiotics. It kills STIs, respiratory tract infections, and skin infections.
  • Cefazolin (73): It belongs to a class of medicines known as cephalosporin antibiotics. Cefazolin is used to treat bacterial infections in many different parts of the body. This medicine is also given before certain types of surgery to prevent infections.
  • Ciprofloxacin (83): often used when other antibiotics have not worked. It’s used to treat bacterial infections, such as chest infections.
  • Moxifloxacin (85): is used to treat certain infections caused by bacteria such as pneumonia, and skin, and abdominal (stomach area) infections.

Since the invention of antibiotics, many lives have been saved from numerous contagious diseases, but MRSA infections are formidable, versatile, and unpredictable. 

MRSA infections are mostly treated with vancomycin, either alone or in combination. 

However, vancomycin’s ability to treat MRSA infections is hindered by intermediate resistance levels, vigilant therapeutic drug monitoring, and MIC creeps.

What Next?

This is not a piece of medical advice. You may need to see an infectious disease specialist if your infection progresses or if complications develop.

In mild cases of staph infections, internists, family doctors, and pediatricians can help.

Follow your provider’s instructions for taking all the medication he or she has prescribed Ask your provider about symptoms or signs that might indicate your infection is becoming worse.

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Last Updated on September 13, 2023 by Our Editorial Team

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